Cyclopes. They're great monsters, and I originally learned about them from Greek Mythology, but in D&D I have for some reason never felt compelled to put them in a campaign. Maybe it's because they're a bit lacking in flavorful lore, at least in 5e.Morkoths. This is the opposite of Cyclopes for me. They're new to me, are cool and would be a great villain, but I have also never found a time in a campaign to add them in.
Living Spells. Fairly new creatures to 5e, only 4 official stat blocks in this edition (Three in E:RftLW, one in W: DotMM). I have even created homebrew stats for more than 12 other living versions spells, but have never found a situation in a campaign where it would fit into the story.
(I may add more later.)
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